Hyaluronic Acid Liposome TR Time Released

Hyaluronic acid is one of the most recognized anti-aging ingredients on the market because of how well it performs. This type of Hyaluronic Acid was designed to deliver all of the benefits of Hyaluronic acid in a time-release package for prolonged and effective delivery. Hyaluronic Acid Liposome TR represents a significant advance in the development of hybrid vesicular delivery technology. Traditionally liposomes enhance the penetration of actives into the skin. However, because liposomes disassociate on the skin’s surface, they do little to protect water-activated materials. Hyaluronic Acid Liposome TR is based on a solid core formed from a silicone copolymer. This copolymer is porous in nature, allowing it to be loaded with various actives. The active is HMW Hyaluronic Acid as a dehydrate in this case. When exposed to a hydrophilic environment, hyaluronic acid can rapidly absorb moisture, causing it to swell. In order to prevent this swelling effect from occurring in the formula instead, the silicone core is coated with a unilamellar phospholipid bilayer; effectively shielding the payload until it reaches the outer layer of skin. This bilayer exhibits a hydrophilic exterior making it suitable for modern oil in water or silicone in water emulsions. Yet application to the skin causes the phospholipid bilayer to shear, thus activating the hyalurosomes to allow for the continued release of hyaluronic acid. Once hydrated, hyaluronic acid will effectively moisturize and plump the skin. The time-release feature of this technology is a result of two factors associated with the silicone core.

The first factor is a variation in the size of the pores within the copolymer. The second is the tortuosity of the pores, or more simply, how convoluted the pores are within the core matrix. To better observe the time-release properties of our Hyalurosome a moisturization study was performed comparing the hydrating benefits of our product to that of hyaluronic acid over the course of a ten-hour period.

BENEFITS
Hyaluronic Acid Liposome TR is beneficial for formulations that require time-released moisturization in the most technologically advanced method on the market. Capitalizing on the popularity of Alpha-HydroxyAcids, Hyalurosome is a must-have for top-of-the-line cosmetics that require a scientific backbone.

As seen in Photo #2, Hyaluronic Acid Liposome TR can deliver time-sensitive moisturization for a period that far exceeds that of traditional Hyaluronic acid. This time delayed-release has led to it being one of the most potent and effective moisturizing agents on the market.

Studies:
To better observe the time-release properties of Hyaluronic Acid Liposome TR a moisturization study was performed comparing the hydrating benefits of our product to that of hyaluronic acid over the course of a ten-hour period. 10 (m/f) subjects between the ages of 22 and 43 applied three different lotions to their fore­arms. The lotions consisted of an o/w emulsion base supplemented with 0.05% Hyalurosome and 0.05% Hyaluronic Acid which was used as the positive control. The blank o/w emulsion base was also used as a negative control. As anticipated both Hyaluronic Acid and Hyaluronic Acid Liposome TR are capable of comparably hydrating the skin. However, the key difference is how long the hydrating properties last. Hyaluronic Acid Liposome TR was capable of continu­ously hydrating the skin over the course of the 10-hour period. However, a decrease in hydration was observed on test sites treated with the hyaluronic acid lotion after 6 hours as is indicated in the Figure below. These results indicate that Hyalurosome is capable of providing sustained activity.

INCI Nomenclature: Polydimethylsiloxane/Polymethylsilsesquioxane Copolymer & Phospholipids & Hyaluronic Acid
Appearance: Semi-Viscous White Liquid
Suggested Use Levels: 0.1-1.0%
Suggested Applications: Time Release Hydration & Moisturization
pH: 5.0 – 7.0
Formulating Guidelines: It can be added in the oil phase or post-emulsification at around 50 -55 degrees Celsius
Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C)
Shelf life: 12 months, properly stored, in a sealed container.
This product should be added to a formulation at the recommended usage rate.

Common Uses: Hyaluronic Acid Liposome promotes healthier, more supple skin. It rehydrates skin to reduce the appearance of wrinkles. It helps increase moisture on the skin. It heals wounds faster when apply to skin wounds and reduces their size.

All products sold are cosmetic grade; External Use Only; Cosmetic & Personal Care Formulations Only.

SDS   
CoA-LOT: BN9403397/CA
CoA-LOT: BN9396504/CA     
CoA-LOT: BN9392414/CA
CoA-LOT: BN24658/CA